Endocrine Abstracts

Background: The melanocortin system is known to be involved in hypothalamic regulation of energy balance, which is implicated in reproductive success. However, the peripheral role for melanocortin receptor (MCR) signalling in the reproductive system has not been described. During a clinical trial of repeated high dose tetracosactide (ACTH1–24) injection, four of nine premenopausal women with Addison’s disease developed menstrual disturbances. We wondered i...